Candida albicans/Macrophage Biointerface on Human and Porcine Decellularized Adipose Matrices

Macrophages, cells effective in sensing, internalizing and killing Candida albicans, are intertwined with the extracellular matrix (ECM) through different signals, which include release of specific cytokines. Due to importance these interactions, employment vitro models mimicking a fungal infection scenario is essential evaluate ECM effects on macrophage response. In this work, we have analyzed human porcine decellularized adipose matrices (DAMs), obtained by either enzymatic or organic solvent treatment, macrophage/Candida albicans interface. The present study has allowed us detect differences activation macrophages cultured human- porcine-derived DAMs, evidencing changes actin cytoskeleton, such as distinct F-actin-rich membrane structures surround pathogen. morphological observed four DAMs key understand defense capability against This work contributed knowledge influence that its components can exert metabolism, immunocompetence capacity respond microenvironment possible scenario.